Long-term use of corticosteroids can worsen blood glucose control in patients with diabetes, leading to hyperglycemia and increased risk of complications.
Closely monitor fasting and postprandial blood glucose levels, especially in the first few weeks of therapy.
Patients may require up to 50% increase in insulin doses during corticosteroid treatment.
Educate patients on symptoms of hyperglycemia and when to seek medical attention.
Consult endocrinologist for complex cases involving brittle diabetes.
Corticosteroids promote insulin resistance by inhibiting glucose uptake in peripheral tissues and stimulate hepatic gluconeogenesis, elevating blood sugar levels.
Risk of hyperglycemia, diabetic ketoacidosis, or need for intensified antidiabetic therapy; may complicate diabetes management and increase cardiovascular risks.
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