The combination may require the dose, timing, or monitoring adjustments described below.
Caution advised when taking Digoxin with Verapamil; monitor for effects.
Digoxin levels may increase when taken with Verapamil.
Risk of bradycardia and heart block may be exacerbated.
Monitoring of digoxin levels is recommended during concurrent use.
Verapamil is a calcium channel blocker that inhibits the metabolism and excretion of Digoxin, leading to increased plasma concentrations of Digoxin. This can result in enhanced pharmacological effects and a higher risk of toxicity due to Digoxin's narrow therapeutic index.
Increased risk of bradycardia, atrioventricular block, and Digoxin toxicity.
Monitor heart rate and Digoxin levels closely. Adjust Digoxin dosage as necessary based on therapeutic response and toxicity signs.
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