Grapefruit juice inhibits the metabolism of sildenafil, leading to increased drug levels and potential enhancement of its effects and side effects.
Grapefruit juice can increase sildenafil bioavailability by up to 23%, prolonging its duration of action.
Effects may last up to 24 hours or more after juice consumption.
Not all citrus juices interact similarly; Seville oranges and pomelos also pose risks.
Inform your doctor of all dietary habits before starting sildenafil.
Grapefruit juice contains furanocoumarins that inhibit the CYP3A4 enzyme in the gastrointestinal tract and liver, reducing the first-pass metabolism of sildenafil and resulting in higher systemic exposure to the drug.
Elevated sildenafil concentrations may amplify adverse effects such as headache, flushing, nasal congestion, visual disturbances, hypotension, or prolonged erection (priapism); severe interactions are rare but possible in sensitive individuals.
Avoid consumption of grapefruit juice while taking sildenafil; if unavoidable, limit intake and monitor for enhanced effects. Consult a healthcare provider for personalized advice, and consider timing doses away from grapefruit consumption.
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