Do not take the combination unless directed. If you already take it, do not stop on your own — contact a pharmacist or prescriber promptly.
Taking Tramadol with SSRIs can increase the risk of serotonin syndrome.
Risk of serotonin syndrome, which can be life-threatening.
Watch for symptoms like agitation, hallucinations, rapid heartbeat, and excessive sweating.
Monitor for increased sedation and seizure risk.
Consult a healthcare provider before using together.
Tramadol increases serotonin levels in the central nervous system. When used with SSRIs, which also elevate serotonin, this can lead to excessive serotonin accumulation, potentially resulting in serotonin syndrome. This condition is characterized by a range of symptoms including confusion, rapid heart rate, and increased blood pressure, and can be life-threatening if not addressed promptly.
Patients may experience symptoms of serotonin syndrome including high fever, seizures, irregular heartbeat, and unconsciousness.
Discontinue either medication if symptoms occur. Seek immediate medical attention for suspected serotonin syndrome. Review alternatives with a healthcare provider.
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