Antifreeze, commonly containing ethylene glycol, poses a severe risk to pets such as dogs and cats. Its sweet flavor lures animals to lick spills, leading to ingestion. Once absorbed, ethylene glycol metabolizes into toxic compounds that damage the kidneys, causing acute renal failure. Even a small lick less than an ounce for a medium-sized dog can be lethal. Initial symptoms mimic drunkenness (wobbliness, vomiting), progressing to metabolic acidosis, seizures, coma, and death if untreated. Prevention is key: immediately dilute and clean spills with water, use pet-safe alternatives like propylene glycol-based antifreeze, and seek emergency vet care if exposure is suspected. Antidotes like fomepizole can save lives if administered early.